Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023034 | 0.92 | FGFR3 (0.49) | L3MBTL1RAB9AHSP90AA1ROCK2SMN1; SMN2 | |
| SCHEMBL17023072 | 0.89 | GAA (0.53) | RAB9AHSP90AA1GAANPSR1KDM4E | |
| SCHEMBL1126897 | 0.86 | L3MBTL1 (0.58) | L3MBTL1RAB9ASMN1; SMN2EGFRFGFR3 | |
| SCHEMBL17023016 | 0.86 | FGFR3 (0.49) | L3MBTL1RAB9ASMN1; SMN2EGFRFGFR3 | |
| SCHEMBL17023015 | 0.85 | L3MBTL1 (0.54) | L3MBTL1RAB9AHSP90AA1SMN1; SMN2EGFR | |
| SCHEMBL17023116 | 0.82 | L3MBTL1 (0.48) | L3MBTL1RAB9ASMN1; SMN2EGFRFGFR3 | |
| SCHEMBL1126691 | 0.78 | FGFR3 (0.63) | L3MBTL1RAB9ASMN1; SMN2EGFRFGFR3 | |
| SCHEMBL17023017 | 0.77 | FGFR3 (0.65) | FGFR3 | |
| SCHEMBL17023065 | 0.76 | FGFR3 (0.48) | L3MBTL1FGFR3KDM4ETSHRHSD17B10 | |
| SCHEMBL29739477 | 0.75 | GAA (0.68) | L3MBTL1RAB9ASMN1; SMN2EGFRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |