Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.34 |
| ▸ | PTGES | O14684 | 2/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023184 | 0.83 | HSP90AA1 (0.38) | ADRA2AADRA2CPTGESADRA1DADRA1A | |
| SCHEMBL1126185 | 0.82 | PTGES (0.43) | ADRA2AADRA2CPTGESHPGDSFGFR3 | |
| SCHEMBL17023018 | 0.79 | FGFR3 (0.45) | HSP90AA1NR3C1FGFR3CYP2C9 | |
| SCHEMBL17023080 | 0.79 | HSP90AA1 (0.38) | ADRA2AHSP90AA1NR3C1FGFR3 | |
| SCHEMBL17023143 | 0.77 | HSP90AA1 (0.44) | ADRA2AADRA2CHSP90AA1FGFR3CYP3A4 | |
| SCHEMBL17023037 | 0.76 | HPGDS (0.44) | ADRA2AADRA2CPTGESADRA1DADRA1A | |
| SCHEMBL17023104 | 0.76 | FGFR3 (0.53) | FGFR3 | |
| SCHEMBL17023129 | 0.75 | FGFR3 (0.46) | HSP90AA1FGFR3CYP3A4 | |
| SCHEMBL17023075 | 0.71 | FGFR3 (0.54) | FGFR3 | |
| SCHEMBL17023116 | 0.71 | L3MBTL1 (0.48) | FGFR3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |