Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 6/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1126960 | 0.86 | FGFR3 (0.57) | FGFR3F10NPC1RAB9A | |
| SCHEMBL17023017 | 0.81 | FGFR3 (0.65) | FGFR3 | |
| SCHEMBL17023059 | 0.78 | FGFR3 (0.54) | FGFR3 | |
| SCHEMBL17023126 | 0.73 | FGFR3 (0.77) | FGFR3F10 | |
| SCHEMBL3346226 | 0.72 | FGFR3 (0.55) | FGFR3F10 | |
| SCHEMBL17023143 | 0.71 | HSP90AA1 (0.44) | FGFR3HSP90AA1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL17023186 | 0.69 | FGFR3 (0.57) | FGFR3 | |
| SCHEMBL17023052 | 0.68 | FGFR3 (0.57) | FGFR3F10 | |
| SCHEMBL17023072 | 0.68 | GAA (0.53) | HSP90AA1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL17023125 | 0.68 | L3MBTL1 (0.47) | FGFR3HSP90AA1KDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |