Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023129 | 0.89 | FGFR3 (0.46) | HSP90AA1MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL17023080 | 0.85 | HSP90AA1 (0.38) | HSP90AA1GAAMAPTMEN1KMT2A | |
| SCHEMBL1126916 | 0.83 | FGFR3 (0.47) | MAPTMEN1KMT2AKDM4EFNTA | |
| SCHEMBL17023018 | 0.82 | FGFR3 (0.45) | HSP90AA1GAAALDH1A1MAPTMEN1 | |
| SCHEMBL17023184 | 0.81 | HSP90AA1 (0.38) | HSP90AA1HSD17B10MAPTMEN1KMT2A | |
| SCHEMBL17023146 | 0.77 | ADRA2A (0.34) | HSP90AA1CYP3A4FGFR3ADRA2AADRA2C | |
| SCHEMBL17023065 | 0.77 | FGFR3 (0.48) | HSD17B10L3MBTL1KDM4EFGFR3LMNA | |
| SCHEMBL17023037 | 0.73 | HPGDS (0.44) | HSP90AA1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL17023104 | 0.73 | FGFR3 (0.53) | FGFR3 | |
| SCHEMBL17023072 | 0.73 | GAA (0.53) | HSP90AA1GAAALDH1A1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |