Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 3/20 | 0.35 |
| ▸ | BACE1 | P56817 | 3/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.35 |
| ▸ | SELP | P16109 | 2/20 | 0.35 |
| ▸ | SELL | P14151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30223686 | 0.82 | LMNA (0.50) | LMNAKMT2AMEN1L3MBTL1PDE4A | |
| SCHEMBL1465569 | 0.82 | LMNA (0.50) | LMNAKMT2AMEN1L3MBTL1PDE4A | |
| SCHEMBL31184746 | 0.74 | LMNA (0.81) | LMNAKMT2AMEN1L3MBTL1PDE4A | |
| SCHEMBL19469640 | 0.70 | AKR1C3 (0.51) | LMNAKMT2AMEN1L3MBTL1PDE4A | |
| SCHEMBL22026867 | 0.70 | DGAT1 (0.44) | LMNAKMT2AMEN1L3MBTL1PDE4A | |
| SCHEMBL16867624 | 0.69 | LMNA (0.65) | LMNAKMT2AMEN1L3MBTL1PDE4A | |
| SCHEMBL77742 | 0.69 | LMNA (0.65) | LMNAKMT2AMEN1L3MBTL1PDE4A | |
| SCHEMBL19863729 | 0.68 | ESR1 (0.58) | LMNAKMT2AMEN1L3MBTL1PPARA | |
| SCHEMBL19863496 | 0.68 | ESR1 (0.53) | LMNAPPARAALDH1A1CASP1ALOX15 | |
| SCHEMBL930424 | 0.68 | ALOX15 (0.42) | LMNAALDH1A1CASP1ALOX15CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007756-B1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2015-08-26 | — | — | EP | disclosed |