SCHEMBL1703209

SCHEMBL1703209

O=c1ccccn1C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.39
POLB P06746 2/20 0.33
NPSR1 Q6W5P4 1/20 0.33
ADORA3 P0DMS8 1/20 0.32
TLR9 Q9NR96 1/20 0.31
CASP1 P29466 1/20 0.31
MGLL Q99685 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
NPC1 O15118 1/20 0.30
MITF O75030 1/20 0.30
LMNA P02545 1/20 0.30
TP53 P04637 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
KDM4E B2RXH2 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL5263179 0.88 CES1 (0.39) HSD17B10POLBNPSR1MEN1KMT2A
SCHEMBL782929 0.76 LMNA (0.37) POLBNPSR1ADORA3TLR9MEN1
SCHEMBL20889885 0.73 LMNA (0.35) POLBNPSR1ADORA3KMT2ANPC1
SCHEMBL10883829 0.73 LMNA (0.35) HSD17B10POLBNPSR1ADORA3MEN1
SCHEMBL2697746 0.70 CYP2B6 (0.41) POLBKMT2ANPC1MITFLMNA
SCHEMBL21081452 0.70 NPC1 (0.36) POLBNPSR1MGLLMEN1KMT2A
SCHEMBL642226 0.69
SCHEMBL28817384 0.68 CALM1 (0.40) MEN1KMT2A
SCHEMBL20542408 0.67 HSD17B10 (0.33) HSD17B10POLBNPSR1
SCHEMBL18102199 0.67 KDM4E (0.38) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018193387-A1 HETEROCYCLIC COMPOUNDS WITH MICROBIOCIDAL PROPERTIES PI INDUSTRIES LTD. (IN) 2018-10-25 WO claimed
EP-3057586-A1 BROMODOMAIN INHIBITORS Celgene Quanticel Research, Inc. (US) 2016-08-24 EP claimed
WO-2015058160-A1 BROMODOMAIN INHIBITORS Quanticel Pharmaceuticals, Inc. (US) 2015-04-23 WO claimed
CN-86106734-A ARYL PYRIDONES 1987-04-01 CN claimed
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
US-20260062425-A1 AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF GENENTECH INC (US) 2026-03-05 US disclosed
US-20260008788-A1 AZA-FUSED RING COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE SUZHOU ARK BIOPHARMACEUTICAL CO LTD (CN) 2026-01-08 US disclosed
EP-4638438-A1 ALPHA4 BETA7 INTEGRIN ANTAGONISTS AND USES THEREOF Xinthera, Inc. (US) 2025-10-29 EP disclosed
US-12338256-B2 Aza-tetracyclic oxazepine compounds and uses thereof GENENTECH, INC. (US) 2025-06-24 US disclosed
US-20250163030-A1 PYRIDIZIN-3(2H)-ONE DERIVATIVES GILEAD SCIENCES, INC. 2025-05-22 US disclosed
US-12263171-B2 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use MERCK SHARP & DOHME LLC (US) 2025-04-01 US disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed
WO-2006012320-A1 PROCESS FOR THE PREPARATION OF 4-TRIFLUOROMETHYL-2(1H)-PYRIDINONE DOW AGROSCIENCES LLC (US) 2006-02-02 WO disclosed
EP-1329160-A2 4-ACYLAMINOPYRAZOLE DERIVATIVES Sankyo Company, Limited (JP) 2003-07-23 EP disclosed
EP-0367410-A1 Aryl pyridones as insecticidal agents IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-05-09 EP disclosed
EP-0316185-A2 N-cyanomethyl-2-pyridinone insecticides THE DOW CHEMICAL COMPANY (US) 1989-05-17 EP disclosed
EP-0272824-A2 Chemical compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-06-29 EP disclosed
CN-86106734-A ARYL PYRIDONES 1987-04-01 CN disclosed
US-4546191-A Trifluoromethyl-2-pyridinone or pyridinthione compounds and process for the preparation of the same ISHIHARA SANGYO KAISHA LTD. (JP) 1985-10-08 US disclosed
US-4546191-A Trifluoromethyl-2-pyridinone or pyridinthione compounds and process for the preparation of the same ISHIHARA SANGYO KAISHA LTD. (JP) 1985-10-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12338256-B2 Aza-tetracyclic oxazepine compounds and uses thereof AZI2, TET3, OXA1L HSD17B10 1355/4885POLB 1891/4885NPSR1 2385/4885
US-20260008788-A1 AZA-FUSED RING COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE PDE4B, PDE4A, CYP4A11 HSD17B10 590/4885POLB 1119/4885NPSR1 392/4885
US-20250163030-A1 PYRIDIZIN-3(2H)-ONE DERIVATIVES PIR, CYP3A43, CYP1A2 HSD17B10 2713/4885POLB 1716/4885NPSR1 1033/4885
US-20260062425-A1 AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF KRAS, NRAS, HRAS HSD17B10 1079/4885POLB 1305/4885NPSR1 3987/4885
US-12263171-B2 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use ADORA2A, ADORA2B, ADORA3 HSD17B10 4107/4885POLB 2229/4885NPSR1 152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.