Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | SCN1A | P35498 | 2/20 | 0.31 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.31 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17035974 | 0.83 | LMNA (0.37) | LMNASMN1; SMN2ALDH1A1METPDE4D | |
| SCHEMBL17035965 | 0.79 | LMNA (0.41) | LMNASMN1; SMN2ALDH1A1METPDE4D | |
| SCHEMBL17035971 | 0.78 | MET (0.43) | LMNASMN1; SMN2ALDH1A1METNR3C1 | |
| SCHEMBL17953926 | 0.75 | PDE4D (0.48) | LMNASMN1; SMN2ALDH1A1METPDE4D | |
| SCHEMBL17035966 | 0.74 | HRH1 (0.49) | LMNASMN1; SMN2ALDH1A1METPDE4D | |
| SCHEMBL17035964 | 0.72 | ALDH1A1 (0.46) | LMNASMN1; SMN2ALDH1A1METPDE4D | |
| SCHEMBL10982436 | 0.72 | SCN1A (0.50) | LMNASMN1; SMN2ADRA1AHTR1AADRA1D | |
| SCHEMBL17035968 | 0.69 | PDE4A (0.38) | LMNASMN1; SMN2ALDH1A1METPDE4D | |
| SCHEMBL17035959 | 0.69 | MET (0.41) | MET | |
| SCHEMBL17586166 | 0.68 | IP6K1 (0.39) | SMN1; SMN2ADRA1AHTR1AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9737544-B2 | Compounds | ASTEX THERAPEUTICS LIMITED (GB) | 2017-08-22 | — | — | US | disclosed |
| US-20160213677-A1 | NEW COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2016-07-28 | — | — | US | disclosed |
| US-9303030-B2 | Compounds | ASTEX THERAPEUTICS LIMITED (GB) | 2016-04-05 | — | — | US | disclosed |
| US-20150239883-A1 | NEW COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2015-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150239883-A1 | NEW COMPOUNDS | NTPCR, MT-ND5, NQO1 | LMNA 671/4885SMN1; SMN2 2305/4885ALDH1A1 1761/4885 |
| US-20160213677-A1 | NEW COMPOUNDS | NTPCR, MT-ND5, NQO1 | LMNA 671/4885SMN1; SMN2 2305/4885ALDH1A1 1761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.