Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | ILK | Q13418 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1564195 | 0.85 | MAPT (0.47) | MAPTLMNAMAPK1ACHESMN1; SMN2 | |
| SCHEMBL8022715 | 0.84 | MAPT (0.50) | MAPTLMNAMAPK1HSD17B10ACHE | |
| SCHEMBL3911808 | 0.82 | MAPT (0.52) | MAPTLMNAMAPK1HSD17B10ACHE | |
| SCHEMBL10803715 | 0.82 | MAPT (0.50) | MAPTLMNAMAPK1HSD17B10ACHE | |
| SCHEMBL3909913 | 0.79 | MAPT (0.49) | MAPTLMNAMAPK1HSD17B10ACHE | |
| SCHEMBL11454704 | 0.73 | TP53 (0.46) | MAPTLMNAMAPK1HSD17B10ACHE | |
| SCHEMBL12988391 | 0.73 | CASP3 (0.57) | MAPTLMNAMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL3911811 | 0.73 | ACHE (0.47) | MAPTLMNAMAPK1HSD17B10ACHE | |
| SCHEMBL8232227 | 0.73 | MEN1 (0.52) | MAPTLMNAMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL3905204 | 0.72 | NPC1 (0.47) | MAPTLMNAMAPK1HSD17B10ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015125785-A1 | PYRAZOLONE DERIVATIVE HAVING MULTIPLE SUBSTITUENTS | 第一三共株式会社 | 2015-08-27 | — | — | WO | disclosed |