Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ILK | Q13418 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TLR2 | O60603 | 4/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10803715 | 0.97 | MAPT (0.50) | MAPTILKNPC1HPGDRAB9A | |
| SCHEMBL17040938 | 0.84 | MAPT (0.54) | MAPTILKNPC1HPGDRAB9A | |
| SCHEMBL3911808 | 0.84 | MAPT (0.52) | MAPTILKNPC1HPGDRAB9A | |
| SCHEMBL12285436 | 0.82 | ALDH1A1 (0.52) | MAPTHPGDLMNAACHEDHODH | |
| SCHEMBL2312071 | 0.81 | SMN1; SMN2 (0.51) | MAPTNPC1HPGDRAB9AHSD17B10 | |
| SCHEMBL3909913 | 0.80 | MAPT (0.49) | MAPTILKNPC1HPGDRAB9A | |
| SCHEMBL10565678 | 0.79 | NAMPT (0.40) | MAPTILKNPC1HPGDRAB9A | |
| SCHEMBL30782219 | 0.79 | ALOX5 (0.50) | LMNATLR2ALDH1A1MEN1NPY2R | |
| SCHEMBL4492930 | 0.79 | MAPT (0.43) | MAPTHPGDRAB9ALMNAMAPK1 | |
| SCHEMBL14571459 | 0.78 | SMN1; SMN2 (0.57) | MAPTNPC1HPGDRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214009-A2 | Enaminones as potential prodrugs of primary and secondary amines | MERCK & CO. INC. (US) | 1987-03-11 | — | — | EP | claimed |
| US-6130228-A | Polycyclic compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2000-10-10 | — | — | US | disclosed |
| EP-0877735-A1 | POLYCYCLIC COMPOUNDS | University of Strathclyde (GB) | 1998-11-18 | — | — | EP | disclosed |
| WO-1997019929-A1 | POLYCYCLIC COMPOUNDS | THE UNIVERSITY OF STRATHCLYDE (GB) | 1997-06-05 | — | — | WO | disclosed |
| EP-0214009-A2 | Enaminones as potential prodrugs of primary and secondary amines | MERCK & CO. INC. (US) | 1987-03-11 | — | — | EP | disclosed |