Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.45 |
| ▸ | SKP1 | P63208 | 2/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704806 | 0.89 | CKS1B (0.47) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL902548 | 0.88 | JAK2 (0.41) | LRRK2 | |
| SCHEMBL1705250 | 0.87 | ACHE (0.47) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL901704 | 0.85 | CKS1B (0.48) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL902751 | 0.84 | CKS1B (0.47) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL901967 | 0.82 | PRKD1 (0.48) | LRRK2 | |
| SCHEMBL901912 | 0.81 | CKS1B (0.52) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL901954 | 0.76 | FAAH (0.41) | DYRK2 | |
| SCHEMBL1704933 | 0.76 | KARS1 (0.53) | GPR119TBK1SYK | |
| SCHEMBL902855 | 0.75 | KARS1 (0.40) | CKS1BSKP1SKP2ACHEGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |