Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.52 |
| ▸ | SKP1 | P63208 | 2/20 | 0.52 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PGK1 | P00558 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704938 | 0.87 | CKS1B (0.40) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL901573 | 0.85 | MAPK1 (0.42) | CKS1BSKP1SKP2LRRK2POLB | |
| SCHEMBL1705250 | 0.84 | ACHE (0.47) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL902751 | 0.83 | CKS1B (0.47) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL901704 | 0.82 | CKS1B (0.48) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL1704806 | 0.81 | CKS1B (0.47) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL1704246 | 0.81 | CKS1B (0.45) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL3443191 | 0.81 | CKS1B (0.64) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL29157436 | 0.79 | LRRK2 (0.54) | CKS1BSKP1SKP2GPR119LRRK2 | |
| SCHEMBL902996 | 0.78 | CKS1B (0.46) | CKS1BSKP1SKP2ACHEGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |