Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 10/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 6/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704574 | 0.94 | KARS1 (0.48) | KARS1ABL1DYRK1AGSK3BNAMPT | |
| SCHEMBL1705115 | 0.90 | KARS1 (0.55) | KARS1NAMPT | |
| SCHEMBL901769 | 0.89 | KARS1 (0.60) | KARS1ABL1SIRT2NAMPT | |
| SCHEMBL902563 | 0.84 | KARS1 (0.65) | KARS1ABL1DYRK1AGSK3B | |
| SCHEMBL1704352 | 0.81 | GRM1 (0.46) | KARS1NAMPT | |
| SCHEMBL901948 | 0.81 | KARS1 (0.46) | KARS1NAMPT | |
| SCHEMBL1704267 | 0.80 | KARS1 (0.63) | KARS1ABL1DYRK1AGSK3B | |
| SCHEMBL1704842 | 0.79 | KARS1 (0.52) | KARS1NAMPT | |
| SCHEMBL1705279 | 0.79 | GRM1 (0.47) | KARS1NAMPT | |
| SCHEMBL902874 | 0.77 | KARS1 (0.43) | KARS1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |