Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 9/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 3/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704574 | 0.94 | KARS1 (0.48) | KARS1NAMPTGRM5GRM1WNT3A | |
| SCHEMBL1704352 | 0.90 | GRM1 (0.46) | KARS1NAMPTGRM5GRM1WNT3A | |
| SCHEMBL901769 | 0.90 | KARS1 (0.60) | KARS1NAMPTJAK1 | |
| SCHEMBL1704307 | 0.90 | KARS1 (0.49) | KARS1NAMPT | |
| SCHEMBL1705279 | 0.86 | GRM1 (0.47) | KARS1NAMPTGRM5GRM1WNT3A | |
| SCHEMBL902876 | 0.85 | KARS1 (0.43) | KARS1NAMPTGRM5GRM1WNT3A | |
| SCHEMBL902874 | 0.85 | KARS1 (0.43) | KARS1NAMPTGRM5GRM1WNT3A | |
| SCHEMBL1704897 | 0.84 | KARS1 (0.42) | KARS1NAMPTGRM5GRM1WNT3A | |
| SCHEMBL1704251 | 0.83 | KARS1 (0.73) | KARS1 | |
| SCHEMBL902803 | 0.81 | PDE10A (0.45) | NAMPTGRM5GRM1PDE10AJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |