Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 11/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705115 | 0.90 | KARS1 (0.55) | KARS1NAMPTJAK1 | |
| SCHEMBL1704307 | 0.89 | KARS1 (0.49) | KARS1SIRT2ABL1NAMPT | |
| SCHEMBL901948 | 0.89 | KARS1 (0.46) | KARS1NAMPTNPC1ALDH1A1ALOX15 | |
| SCHEMBL1704842 | 0.85 | KARS1 (0.52) | KARS1NAMPTNPC1ALDH1A1ALOX15 | |
| SCHEMBL901298 | 0.84 | KARS1 (0.64) | KARS1SIRT2PRKD3ABL1PRKCG | |
| SCHEMBL1704574 | 0.83 | KARS1 (0.48) | KARS1ABL1PDGFRBNAMPTJAK1 | |
| SCHEMBL901335 | 0.82 | KARS1 (0.44) | KARS1NAMPT | |
| SCHEMBL901421 | 0.80 | KARS1 (0.82) | KARS1SIRT2PRKD1JAK2JAK1 | |
| SCHEMBL1705014 | 0.80 | ALDH1A1 (0.44) | KARS1SIRT2NAMPTNPC1ALDH1A1 | |
| SCHEMBL901535 | 0.78 | KARS1 (0.58) | KARS1SIRT2ABL1BCRPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |