Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 5/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.44 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | NMT1 | P30419 | 8/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901187 | 0.84 | KARS1 (0.53) | KARS1DYRK1APRKD3PRKD1PRKD2 | |
| SCHEMBL902121 | 0.76 | KARS1 (0.50) | KARS1DYRK1APRKD3PRKD1PRKD2 | |
| SCHEMBL30230278 | 0.74 | ADRB1 (0.59) | KARS1DYRK1AHRH3NMT1ADRB1 | |
| SCHEMBL1026043 | 0.74 | ADRB1 (0.59) | KARS1DYRK1AHRH3NMT1ADRB1 | |
| Hydrochloric Acid SCHEMBL31061151 | 0.73 | ADRB1 (0.58) | KARS1DYRK1AHRH3NMT1ADRB1 | |
| Hydrochloric Acid SCHEMBL20339443 | 0.73 | ADRB1 (0.58) | KARS1DYRK1AHRH3NMT1ADRB1 | |
| SCHEMBL16716464 | 0.71 | SMO (0.60) | KARS1DYRK1ANMT1TLR9TLR8 | |
| SCHEMBL10268986 | 0.71 | KARS1 (0.75) | KARS1PRKD1PRKD2 | |
| SCHEMBL12685317 | 0.70 | KARS1 (0.60) | KARS1DYRK1APRKD3PRKD1PRKD2 | |
| SCHEMBL26204494 | 0.69 | NMT1 (0.55) | DYRK1ANMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |