Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 10/20 | 0.50 |
| ▸ | ATR | Q13535 | 2/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.42 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | PRKCH | P24723 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704401 | 0.76 | KARS1 (0.52) | KARS1ATRPRKD3PRKD1DYRK1A | |
| SCHEMBL901187 | 0.71 | KARS1 (0.53) | KARS1ATRPRKD3PRKD1DYRK1A | |
| SCHEMBL1705644 | 0.70 | PIM1 (0.41) | KARS1PIM1PIM3PIM2 | |
| SCHEMBL1704904 | 0.69 | KARS1 (0.68) | KARS1ATRDYRK1ANMT1 | |
| SCHEMBL902386 | 0.69 | KARS1 (0.75) | KARS1PRKD1PRKD2 | |
| SCHEMBL1704290 | 0.68 | KARS1 (0.62) | KARS1ATRDYRK1ANMT1 | |
| SCHEMBL1704095 | 0.67 | KARS1 (0.62) | KARS1PRKD1PRKD2 | |
| SCHEMBL1704222 | 0.67 | KARS1 (1.00) | KARS1PRKD3PRKD1PRKD2 | |
| SCHEMBL16716464 | 0.65 | SMO (0.60) | KARS1DYRK1ANMT1 | |
| SCHEMBL2876435 | 0.64 | NCF1 (0.58) | DYRK1ANMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | claimed |