Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 7/20 | 0.73 |
| ▸ | SYK | P43405 | 12/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901891 | 0.89 | KARS1 (0.73) | KARS1SYK | |
| SCHEMBL1704909 | 0.88 | KARS1 (0.67) | KARS1SYKMTORSMG1 | |
| SCHEMBL901783 | 0.87 | KARS1 (0.56) | KARS1SYK | |
| SCHEMBL1704662 | 0.86 | KARS1 (0.72) | KARS1SYKSMG1 | |
| SCHEMBL901740 | 0.85 | KARS1 (1.00) | KARS1SYKMTORSMG1 | |
| SCHEMBL901900 | 0.84 | KARS1 (0.53) | KARS1SYK | |
| SCHEMBL902071 | 0.84 | KARS1 (0.72) | KARS1 | |
| SCHEMBL901785 | 0.83 | KARS1 (0.53) | KARS1MTORSMG1 | |
| SCHEMBL1704434 | 0.83 | KARS1 (0.68) | KARS1SYKSMG1 | |
| SCHEMBL901953 | 0.82 | KARS1 (0.56) | KARS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |