Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.52 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901727 | 0.88 | KARS1 (1.00) | KARS1ADRB1SYKMAP3K12 | |
| SCHEMBL1704409 | 0.85 | KARS1 (0.73) | KARS1MTORSMG1SYK | |
| SCHEMBL901824 | 0.85 | KARS1 (1.00) | KARS1PRKD1PRKD2 | |
| SCHEMBL902600 | 0.82 | KARS1 (1.00) | KARS1 | |
| SCHEMBL1704227 | 0.82 | KARS1 (0.73) | KARS1PRKD1PRKD2 | |
| SCHEMBL902162 | 0.81 | KARS1 (1.00) | KARS1MAP3K12 | |
| SCHEMBL1704909 | 0.80 | KARS1 (0.67) | KARS1MTORSMG1SYK | |
| SCHEMBL1704417 | 0.80 | KARS1 (0.76) | KARS1 | |
| SCHEMBL902909 | 0.78 | KARS1 (0.63) | KARS1SYK | |
| SCHEMBL901925 | 0.78 | KARS1 (0.67) | KARS1SYKMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |