Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.46 |
| ▸ | GRM5 | P41594 | 9/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901340 | 0.85 | ALDH1A1 (0.50) | CNR1KDM4EALDH1A1 | |
| SCHEMBL901343 | 0.82 | NAMPT (0.44) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL902803 | 0.81 | PDE10A (0.45) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL1704146 | 0.81 | NAMPT (0.43) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL2811392 | 0.81 | PDK4 (0.60) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL13261659 | 0.80 | PDK4 (0.56) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL15534537 | 0.80 | NAMPT (0.52) | PDK4NAMPTGRM1GRM5JAK1 | |
| SCHEMBL2239831 | 0.78 | NAMPT (0.66) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL7396863 | 0.78 | NAMPT (0.61) | PDK4NAMPTGRM1GRM5HTR6 | |
| SCHEMBL7831576 | 0.78 | PDK4 (0.58) | PDK4NAMPTGRM1GRM5HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |