Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 7/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 7/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902789 | 0.91 | ALDH1A1 (0.42) | SOS1KDM4EALDH1A1 | |
| SCHEMBL901343 | 0.87 | NAMPT (0.44) | NAMPTJAK1PDK4SOS1GRM5 | |
| SCHEMBL1704903 | 0.86 | GRM1 (0.45) | NAMPTJAK1PDK4SOS1GRM5 | |
| SCHEMBL1704989 | 0.85 | NAMPT (0.44) | NAMPTJAK1PDK4SOS1GRM5 | |
| SCHEMBL902803 | 0.85 | PDE10A (0.45) | NAMPTJAK1PDK4SOS1GRM5 | |
| SCHEMBL902875 | 0.82 | IGF1R (0.42) | NAMPT | |
| SCHEMBL1704495 | 0.81 | PDK4 (0.48) | NAMPTJAK1PDK4SOS1GRM5 | |
| SCHEMBL1704634 | 0.77 | ALDH1A1 (0.38) | NAMPTKDM4EALDH1A1 | |
| SCHEMBL1704967 | 0.75 | ALDH1A1 (0.44) | CDK7KDM4EALDH1A1 | |
| SCHEMBL902774 | 0.75 | ALDH1A1 (0.37) | SOS1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |