Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 6/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901343 | 0.90 | NAMPT (0.44) | PDE10ANAMPTGRM5GRM1JAK1 | |
| SCHEMBL1705014 | 0.88 | ALDH1A1 (0.44) | NAMPTCDK9 | |
| SCHEMBL1704352 | 0.86 | GRM1 (0.46) | PDE10ANAMPTGRM5GRM1JAK1 | |
| SCHEMBL1705279 | 0.85 | GRM1 (0.47) | PDE10ANAMPTGRM5GRM1JAK1 | |
| SCHEMBL1704146 | 0.85 | NAMPT (0.43) | PDE10ANAMPTGRM5GRM1JAK1 | |
| SCHEMBL1705115 | 0.81 | KARS1 (0.55) | PDE10ANAMPTGRM5GRM1JAK1 | |
| SCHEMBL1704495 | 0.81 | PDK4 (0.48) | PDE10ANAMPTGRM5GRM1JAK1 | |
| SCHEMBL901704 | 0.80 | CKS1B (0.48) | — | |
| SCHEMBL1704574 | 0.78 | KARS1 (0.48) | NAMPTGRM5GRM1JAK1CYP11B2 | |
| SCHEMBL1704967 | 0.78 | ALDH1A1 (0.44) | CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |