Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 6/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902803 | 0.90 | PDE10A (0.45) | NAMPTTNK2JAK1PDE10APDK4 | |
| SCHEMBL1704967 | 0.89 | ALDH1A1 (0.44) | CDK9 | |
| SCHEMBL1704146 | 0.87 | NAMPT (0.43) | NAMPTTNK2JAK1PDE10APDK4 | |
| SCHEMBL1704197 | 0.85 | KARS1 (0.49) | NAMPTJAK1GRM5GRM1SYK | |
| SCHEMBL1704495 | 0.82 | PDK4 (0.48) | NAMPTTNK2JAK1PDE10APDK4 | |
| SCHEMBL902751 | 0.82 | CKS1B (0.47) | SYKWNT3A | |
| SCHEMBL1705014 | 0.77 | ALDH1A1 (0.44) | NAMPTCDK9 | |
| SCHEMBL902789 | 0.77 | ALDH1A1 (0.42) | SOS1 | |
| SCHEMBL15602478 | 0.76 | WNT3A (0.42) | NAMPTTNK2JAK1PDE10AGRM5 | |
| SCHEMBL1704352 | 0.76 | GRM1 (0.46) | NAMPTTNK2JAK1PDE10APDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |