Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPRA | P18433 | 1/20 | 0.34 |
| ▸ | PTPRB | P23467 | 1/20 | 0.34 |
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
| ▸ | ARG2 | P78540 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022118 | 0.85 | PPARG (0.40) | CES1SMN1; SMN2HIF1APTPN1PTPN2 | |
| SCHEMBL5674360 | 0.77 | CES1 (0.39) | CES1PTPN1PTPN2PTPRBPTPRC | |
| SCHEMBL6741779 | 0.75 | PPARG (0.51) | CES1SMN1; SMN2HIF1APTPN1PTPN2 | |
| SCHEMBL16754032 | 0.75 | PPARG (0.51) | CES1SMN1; SMN2HIF1APTPN1PTPN2 | |
| SCHEMBL17044967 | 0.70 | SMN1; SMN2 (0.47) | CES1SMN1; SMN2HIF1APTPN1ARG1 | |
| SCHEMBL15620629 | 0.70 | SMN1; SMN2 (0.47) | CES1SMN1; SMN2HIF1APTPN1ARG1 | |
| SCHEMBL7334079 | 0.70 | FDPS (0.50) | CES1PTPN1PTPRCTSHR | |
| SCHEMBL11606600 | 0.67 | ALDH1A1 (0.50) | CES1SMN1; SMN2HIF1ACES2AKR1B1 | |
| SCHEMBL11011925 | 0.67 | GRM2 (0.40) | PPARGPPARA | |
| Aniline SCHEMBL2334841 | 0.66 | SLC6A2 (0.42) | CES1SMN1; SMN2HIF1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249157-B2 | Tricyclic heterocycle compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-02-02 | — | — | US | disclosed |
| US-20150246930-A1 | TRICYCLIC HETEROCYCLE COMPOUNDS | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2015-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246930-A1 | TRICYCLIC HETEROCYCLE COMPOUNDS | RCOR3, NR4A3, NCOA3 | CES1 1120/4885SMN1; SMN2 4339/4885HIF1A 1536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.