Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705351 | 0.94 | KARS1 (0.52) | KARS1HDAC1TYK2MAPK8RET | |
| SCHEMBL1704896 | 0.92 | KARS1 (0.60) | KARS1HDAC1MAPK8RETPARP1 | |
| SCHEMBL1705099 | 0.90 | KARS1 (0.47) | KARS1HDAC1 | |
| SCHEMBL902062 | 0.86 | KARS1 (0.57) | KARS1TYK2JAK1WNT1GSK3B | |
| SCHEMBL902626 | 0.83 | KARS1 (0.73) | KARS1DYRK1A | |
| SCHEMBL901253 | 0.83 | KARS1 (0.65) | KARS1TYK2MAPK8JAK1WNT1 | |
| SCHEMBL901888 | 0.82 | KARS1 (0.68) | KARS1HDAC1TYK2JAK1WNT1 | |
| SCHEMBL1704251 | 0.78 | KARS1 (0.73) | KARS1DYRK1A | |
| SCHEMBL1704584 | 0.78 | PARP1 (0.45) | KARS1HDAC1TYK2MAPK8RET | |
| SCHEMBL1705003 | 0.78 | KARS1 (0.65) | KARS1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |