Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | KARS1 | Q15046 | 8/20 | 0.37 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901409 | 0.89 | KARS1 (0.41) | HDAC1KARS1MAP3K13MAP3K12TYK2 | |
| SCHEMBL901885 | 0.84 | KARS1 (0.39) | GPR119KARS1BUB1 | |
| SCHEMBL901704 | 0.82 | CKS1B (0.48) | GPR119KARS1 | |
| SCHEMBL1704896 | 0.80 | KARS1 (0.60) | PARP1HDAC1RETMAPK8KARS1 | |
| SCHEMBL11963801 | 0.79 | HDAC1 (0.43) | PARP1HDAC1RETMAPK8GPR119 | |
| SCHEMBL11963802 | 0.79 | HDAC1 (0.43) | PARP1HDAC1RETMAPK8GPR119 | |
| SCHEMBL902855 | 0.79 | KARS1 (0.40) | GPR119KARS1 | |
| SCHEMBL1704520 | 0.78 | KARS1 (0.60) | PARP1HDAC1RETMAPK8KARS1 | |
| SCHEMBL1705351 | 0.78 | KARS1 (0.52) | PARP1HDAC1RETMAPK8KARS1 | |
| SCHEMBL1704237 | 0.77 | WNT1 (0.41) | KARS1WNT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |