Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 3/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.41 |
| ▸ | FEN1 | P39748 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 2/20 | 0.38 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901793 | 0.87 | ADORA2B (0.55) | ADORA2BPIM1PIM3PIM2ALOX5AP | |
| SCHEMBL1704888 | 0.80 | MEN1 (0.50) | ADORA2BPIM1DYRK1A | |
| SCHEMBL28684286 | 0.80 | DYRK1A (0.50) | PIM1PIM3PIM2ALOX5APFEN1 | |
| SCHEMBL29602147 | 0.80 | DYRK1A (0.50) | PIM1PIM3PIM2ALOX5APFEN1 | |
| SCHEMBL15436237 | 0.75 | PIM1 (0.45) | ADORA2BPIM1PIM3PIM2ALOX5AP | |
| Hydrochloric Acid SCHEMBL27850418 | 0.73 | PIM1 (0.44) | ADORA2BPIM1PIM3PIM2ALOX5AP | |
| Hydrochloric Acid SCHEMBL15436253 | 0.73 | PIM1 (0.44) | ADORA2BPIM1PIM3PIM2ALOX5AP | |
| SCHEMBL901619 | 0.71 | ADORA2B (0.58) | ADORA2BMAPTADORA2A | |
| SCHEMBL4053436 | 0.70 | ADORA2B (0.60) | ADORA2BPIM1ALOX5APFEN1DYRK1A | |
| SCHEMBL22334571 | 0.68 | PIK3CD (0.45) | PIM1PIM3PIM2ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |