Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.43 |
| ▸ | FEN1 | P39748 | 3/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15436253 | 0.98 | PIM1 (0.44) | PIM1PIM2PIM3MBOAT4HSP90AA1 | |
| Hydrochloric Acid SCHEMBL27850418 | 0.98 | PIM1 (0.44) | PIM1PIM2PIM3MBOAT4HSP90AA1 | |
| Maleic Acid SCHEMBL28393695 | 0.87 | PIM2 (0.44) | PIM1PIM2PIM3MBOAT4HSP90AA1 | |
| Maleic Acid SCHEMBL30608269 | 0.87 | PIM2 (0.44) | PIM1PIM2PIM3MBOAT4HSP90AA1 | |
| SCHEMBL7915364 | 0.82 | MBOAT4 (0.47) | PIM1PIM2PIM3MBOAT4HSP90AA1 | |
| SCHEMBL901793 | 0.78 | ADORA2B (0.55) | PIM1PIM2PIM3MBOAT4HSP90AA1 | |
| SCHEMBL15436242 | 0.76 | DHFR (0.46) | MBOAT4HSP90AA1ALOX5APFEN1PIK3CD | |
| SCHEMBL798061 | 0.76 | KDM4E (0.50) | HSP90AA1PI4KAPI4KBKDM4EGLA | |
| SCHEMBL19376940 | 0.76 | ALOX5AP (0.44) | MBOAT4HSP90AA1ALOX5APFEN1PIK3CD | |
| SCHEMBL27960699 | 0.75 | NCF1 (0.45) | PIM1PIM2PIM3ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102307869-B | Aminopyrazine derivative and medicine | NIPPON SHINYAKU CO.,LTD. (JP) | 2014-10-22 | — | — | CN | claimed |
| CN-102307869-B | Aminopyrazine derivative and medicine | NIPPON SHINYAKU CO.,LTD. (JP) | 2014-10-22 | — | — | CN | disclosed |
| EP-2394999-B1 | AMINOPYRAZINE DERIVATIVE AND MEDICINE | NIPPON SHINYAKU CO LTD (JP) | 2014-01-29 | — | — | EP | disclosed |
| CN-102307869-A | Aminopyrazine derivative and medicine | NIPPON SHINYAKU CO LTD | 2012-01-04 | — | — | CN | disclosed |
| EP-2394999-A1 | AMINOPYRAZINE DERIVATIVE AND MEDICINE | Nippon Shinyaku Co., Ltd. (JP) | 2011-12-14 | — | — | EP | disclosed |