Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.50 |
| ▸ | PI4KA | P42356 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | LATS1 | O95835 | 1/20 | 0.45 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28684286 | 1.00 | DYRK1A (0.50) | DYRK1AHSP90AA1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL20169521 | 0.82 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL1704539 | 0.80 | ADORA2B (0.51) | DYRK1AHSP90AA1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL4402187 | 0.76 | DYRK1A (0.63) | DYRK1API4KAPI4KBMAPTPIK3C3 | |
| SCHEMBL30935767 | 0.76 | DYRK1A (0.63) | DYRK1API4KAPI4KBMAPTPIK3C3 | |
| SCHEMBL1592142 | 0.76 | ASIC3 (0.62) | DYRK1AMAPTMKNK1MKNK2KDM4E | |
| SCHEMBL4707361 | 0.76 | MEN1 (0.59) | DYRK1APIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL22334571 | 0.76 | PIK3CD (0.45) | HSP90AA1PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL28051992 | 0.75 | ADORA3 (0.59) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL902145 | 0.75 | KARS1 (0.44) | DYRK1AHSP90AA1PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-116547282-A | Heterocyclic compounds and their use for the treatment of helminth infections and diseases | 新基公司 | 2023-08-04 | — | — | CN | disclosed |
| CN-113956236-B | Phthalimide compound and application thereof | 中国医学科学院药物研究所 | 2023-01-06 | — | — | CN | disclosed |
| CN-113929662-B | Succinimide or maleimide compound and use thereof | 中国医学科学院药物研究所 | 2023-01-06 | — | — | CN | disclosed |
| CN-109867661-B | Amide compounds for regulating WNT signal pathway and application thereof | 中国医学科学院药物研究所 | 2022-07-19 | — | — | CN | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |