Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 5/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.41 |
| ▸ | FEN1 | P39748 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PRKCH | P24723 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704539 | 0.87 | ADORA2B (0.51) | ADORA2BADORA2APIM1PIM3PIM2 | |
| SCHEMBL18039107 | 0.79 | ADORA2B (0.68) | ADORA2BADORA2AADORA1NQO2MAPK1 | |
| SCHEMBL15436237 | 0.78 | PIM1 (0.45) | ADORA2BADORA2AADORA1PIM1PIM3 | |
| SCHEMBL901619 | 0.78 | ADORA2B (0.58) | ADORA2BADORA2AADORA1MAPT | |
| Hydrochloric Acid SCHEMBL15436253 | 0.77 | PIM1 (0.44) | ADORA2BADORA2AADORA1PIM1PIM3 | |
| Hydrochloric Acid SCHEMBL27850418 | 0.77 | PIM1 (0.44) | ADORA2BADORA2AADORA1PIM1PIM3 | |
| SCHEMBL902146 | 0.76 | ADORA2B (0.47) | ADORA2BADORA2AADORA1PIM1PIM3 | |
| SCHEMBL18039101 | 0.76 | ADORA2B (0.59) | ADORA2BADORA2AADORA1ALOX5APFEN1 | |
| SCHEMBL18039071 | 0.75 | ADORA2B (0.51) | ADORA2BADORA2AADORA1NQO2MAPT | |
| SCHEMBL18039087 | 0.75 | ADORA2B (0.58) | ADORA2BADORA2AADORA1NQO2MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10253017-B2 | Derivatives of 2-aminopyridine as adenosine A2B receptor antagonists and ligands of the melatonin MT3 receptors | PALOBIOFARMA, S.L. (ES) | 2019-04-09 | — | — | US | claimed |
| US-20180037569-A1 | DERIVATIVES OF 2-AMINOPYRIDINE AS ADENOSINE A2B RECEPTOR ANTAGONISTS AND LIGANDS OF THE MELATONIN MT3 RECEPTORS | PALOBIOFARMA, S.L. (ES) | 2018-02-08 | — | — | US | claimed |
| EP-3262034-A1 | DERIVATIVES OF 2-AMINOPYRIDINE AS ADENOSINE A2B RECEPTOR ANTAGONISTS AND LIGANDS OF THE MELATONIN MT3 RECEPTORS | Palobiofarma, S.L. (ES) | 2018-01-03 | — | — | EP | claimed |
| WO-2016135048-A1 | DERIVATIVES OF 2-AMINOPYRIDINE AS ADENOSINE A2B RECEPTOR ANTAGONISTS AND LIGANDS OF THE MELATONIN MT3 RECEPTORS | PALOBIOFARMA, S.L. (ES) | 2016-09-01 | — | — | WO | claimed |
| US-10253017-B2 | Derivatives of 2-aminopyridine as adenosine A2B receptor antagonists and ligands of the melatonin MT3 receptors | PALOBIOFARMA, S.L. (ES) | 2019-04-09 | — | — | US | disclosed |
| US-20180037569-A1 | DERIVATIVES OF 2-AMINOPYRIDINE AS ADENOSINE A2B RECEPTOR ANTAGONISTS AND LIGANDS OF THE MELATONIN MT3 RECEPTORS | PALOBIOFARMA, S.L. (ES) | 2018-02-08 | — | — | US | disclosed |
| EP-3262034-A1 | DERIVATIVES OF 2-AMINOPYRIDINE AS ADENOSINE A2B RECEPTOR ANTAGONISTS AND LIGANDS OF THE MELATONIN MT3 RECEPTORS | Palobiofarma, S.L. (ES) | 2018-01-03 | — | — | EP | disclosed |
| WO-2016135048-A1 | DERIVATIVES OF 2-AMINOPYRIDINE AS ADENOSINE A2B RECEPTOR ANTAGONISTS AND LIGANDS OF THE MELATONIN MT3 RECEPTORS | PALOBIOFARMA, S.L. (ES) | 2016-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10253017-B2 | Derivatives of 2-aminopyridine as adenosine A2B receptor antagonists and ligands of the melatonin MT3 receptors | ADORA2B, MTNR1A, ADORA3 | ADORA2B 1/4885ADORA2A 5/4885ADORA1 6/4885 |
| US-20180037569-A1 | DERIVATIVES OF 2-AMINOPYRIDINE AS ADENOSINE A2B RECEPTOR ANTAGONISTS AND LIGANDS OF THE MELATONIN MT3 RECEPTORS | ADORA2B, MTNR1A, ADORA3 | ADORA2B 1/4885ADORA2A 5/4885ADORA1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.