Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 3/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705093 | 0.93 | KARS1 (0.53) | KARS1GPR119SYKLRRK2 | |
| SCHEMBL901397 | 0.90 | KARS1 (0.55) | KARS1KDM4ESYK | |
| SCHEMBL1704775 | 0.89 | KARS1 (0.57) | KARS1GPR119KDM4ESYK | |
| SCHEMBL902991 | 0.89 | KARS1 (0.67) | KARS1GPR119KDM4ESYK | |
| SCHEMBL1704902 | 0.85 | KARS1 (0.73) | KARS1GPR119KDM4ESYK | |
| SCHEMBL1704732 | 0.85 | KARS1 (0.52) | KARS1GPR119SYKLRRK2 | |
| SCHEMBL1704536 | 0.85 | LMNA (0.45) | GPR119KDM4ELRRK2 | |
| SCHEMBL902972 | 0.84 | KARS1 (0.51) | KARS1GPR119SYKLRRK2 | |
| SCHEMBL901333 | 0.84 | KARS1 (0.65) | KARS1GPR119SYKLRRK2 | |
| SCHEMBL901508 | 0.83 | KARS1 (0.56) | KARS1GPR119SYKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |