Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901781 | 0.89 | LMNA (0.48) | LMNAMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL1704646 | 0.87 | GPR119 (0.42) | LMNAGPR119LRRK2CKS1BSKP1 | |
| SCHEMBL1704616 | 0.85 | KARS1 (0.53) | GPR119LRRK2KDM4E | |
| SCHEMBL902996 | 0.82 | CKS1B (0.46) | GPR119LRRK2CKS1BSKP1SKP2 | |
| SCHEMBL902930 | 0.80 | FLT3 (0.46) | GPR119LRRK2CKS1BSKP1SKP2 | |
| SCHEMBL1705093 | 0.76 | KARS1 (0.53) | GPR119LRRK2TBK1 | |
| SCHEMBL1704917 | 0.76 | LMNA (0.43) | LMNAMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL18031540 | 0.75 | SCN9A (0.56) | LMNASMN1; SMN2CKS1BSKP1SKP2 | |
| SCHEMBL902991 | 0.74 | KARS1 (0.67) | GPR119MEN1KMT2AKDM4E | |
| SCHEMBL1704775 | 0.74 | KARS1 (0.57) | GPR119KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |