SCHEMBL17047772

SCHEMBL17047772

CC1C(=O)NC(O)C1(C)c1cccs1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.37
HSD17B10 Q99714 3/20 0.36
KMT2A Q03164 3/20 0.34
MEN1 O00255 2/20 0.34
ALDH1A1 P00352 2/20 0.34
HTT P42858 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
DDB1 Q16531 1/20 0.32
CRBN Q96SW2 1/20 0.32
KDM4E B2RXH2 2/20 0.32
LMNA P02545 3/20 0.31
TSHR P16473 2/20 0.31
HPGD P15428 1/20 0.31
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
KIF11 P52732 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7708737 0.68 MEN1 (0.40) HCAR2HSD17B10KMT2AMEN1ALDH1A1
SCHEMBL9633434 0.59 SLC6A3 (0.35) HCAR2KMT2AMEN1ALDH1A1KDM4E
SCHEMBL9631894 0.58 SLC6A3 (0.37) HCAR2KMT2AMEN1ALDH1A1LMNA
SCHEMBL9632881 0.58 SLC6A3 (0.37) HCAR2KMT2AMEN1ALDH1A1LMNA
SCHEMBL9631898 0.58 SLC6A3 (0.37) HCAR2KMT2AMEN1ALDH1A1LMNA
SCHEMBL11590164 0.58 ALDH1A1 (0.37) HCAR2HSD17B10KMT2AMEN1ALDH1A1
SCHEMBL15165509 0.57 MEN1 (0.45) HCAR2HSD17B10KMT2AMEN1ALDH1A1
SCHEMBL11315800 0.57
SCHEMBL13580146 0.57 ALDH1A1 (0.51) HSD17B10KMT2AMEN1ALDH1A1HTT
SCHEMBL3075586 0.57 ALDH1A1 (0.51) HSD17B10KMT2AMEN1ALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3110808-B1 PLANT GROWTH REGULATING COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-08-29 EP disclosed
US-9751867-B2 Plant growth regulating compounds SYNGENTA PARTICIPATIONS AG (CH) 2017-09-05 US disclosed
EP-3110808-A1 PLANT GROWTH REGULATING COMPOUNDS Syngenta Participations AG (CH) 2017-01-04 EP disclosed
US-20160368900-A1 PLANT GROWTH REGULATING COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2016-12-22 US disclosed
WO-2015128321-A1 PLANT GROWTH REGULATING COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2015-09-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160368900-A1 PLANT GROWTH REGULATING COMPOUNDS GHDC, GAK, EIF4G2 HCAR2 1004/4885HSD17B10 957/4885KMT2A 3798/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.