Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GNRHR | P30968 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL977739 | 1.00 | ALDH1A1 (0.53) | ALDH1A1TRPM8F2MEN1KMT2A | |
| SCHEMBL979436 | 0.72 | ALDH1A1 (0.62) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL10641373 | 0.69 | KDM4E (0.64) | ALDH1A1KMT2AKDM4EAPOBEC3AAPOBEC3G | |
| SCHEMBL978793 | 0.68 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL977464 | 0.68 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL979555 | 0.68 | HTT (0.60) | ALDH1A1KMT2AKDM4EMAPTHTT | |
| SCHEMBL10642457 | 0.67 | RPS6KA5 (0.49) | ALDH1A1TRPM8KMT2AKDM4EMAPT | |
| SCHEMBL1892701 | 0.66 | PTGDR2 (0.55) | ALDH1A1F2KDM4EAPOBEC3AAPOBEC3G | |
| SCHEMBL1707296 | 0.66 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL978780 | 0.66 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440294-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010144680-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-16 | — | — | WO | disclosed |