Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707588 | 0.79 | KDM4E (0.44) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL978793 | 0.79 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL977464 | 0.76 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL977739 | 0.72 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL1704857 | 0.72 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL3448552 | 0.69 | S1PR1 (0.77) | CYP2D6CYP2C19S1PR1 | |
| SCHEMBL31325564 | 0.69 | ALDH1A1 (0.63) | ALDH1A1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL1707586 | 0.68 | HTT (0.62) | KMT2ACYP2D6HTTTP53POLB | |
| SCHEMBL13071432 | 0.68 | CYP2C9 (0.44) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL979423 | 0.68 | HTT (0.62) | KMT2ACYP2D6HTTTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9636345-B2 | Benzimidazole derivatives useful TRPM8 channel modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-02 | — | — | US | disclosed |
| US-20150150882-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-06-04 | — | — | US | disclosed |
| US-8981113-B2 | Benzimidazole derivatives useful as TRPM8 channel modulators | JANSSEN PHARMACEUTICA NV (BE) | 2015-03-17 | — | — | US | disclosed |
| US-20130245085-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2013-09-19 | — | — | US | disclosed |
| EP-2440294-B1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2013-07-24 | — | — | EP | disclosed |
| EP-2440295-B1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2013-07-24 | — | — | EP | disclosed |
| US-8450497-B2 | Benzimidazole derivatives useful as TRPM8 channel modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-05-28 | — | — | US | disclosed |
| US-8242157-B2 | Benzimidazole derivatives useful as TRPM8 channel modulators | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-14 | — | — | US | disclosed |
| EP-2440294-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-04-18 | — | — | EP | disclosed |
| EP-2440295-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-04-18 | — | — | EP | disclosed |
| US-20110003801-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-01-06 | — | — | US | disclosed |
| US-20110003800-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-01-06 | — | — | US | disclosed |
| WO-2010144679-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-16 | — | — | WO | disclosed |
| WO-2010144680-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003800-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | TRPM8, TRPM4, TRPM6 | ALDH1A1 1798/4885MEN1 657/4885KMT2A 1701/4885 |
| US-20130245085-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | TRPM8, TRPM4, TRPM6 | ALDH1A1 1798/4885MEN1 657/4885KMT2A 1701/4885 |
| US-20150150882-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL TRPM8 CHANNEL MODULATORS | TRPM8, TRPM4, TRPM6 | ALDH1A1 2178/4885MEN1 670/4885KMT2A 1616/4885 |
| US-20110003801-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | TRPM8, TRPM4, TRPM6 | ALDH1A1 1798/4885MEN1 657/4885KMT2A 1701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.