Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | BRD1 | O95696 | 1/20 | 0.45 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.45 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.45 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.45 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL978780 | 1.00 | ALDH1A1 (0.58) | ALDH1A1METAP2MAPTMEN1KMT2A | |
| SCHEMBL977464 | 0.84 | ALDH1A1 (0.61) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL1704422 | 0.74 | KDM4E (0.46) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL26813752 | 0.72 | HSD17B10 (0.58) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL26813759 | 0.72 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL7579963 | 0.71 | METAP2 (0.69) | ALDH1A1METAP2MAPTLMNAFFAR4 | |
| SCHEMBL20233035 | 0.70 | RAB9A (0.51) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL27827007 | 0.70 | FBP1 (0.61) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL578654 | 0.70 | FFAR4 (0.68) | ALDH1A1METAP2MAPTMEN1KMT2A | |
| SCHEMBL1104822 | 0.70 | ATM (0.55) | ALDH1A1MAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440295-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010144679-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-16 | — | — | WO | disclosed |