Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 6/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901697 | 0.88 | KARS1 (0.65) | KARS1TBK1CKS1BSKP1SKP2 | |
| SCHEMBL901785 | 0.87 | KARS1 (0.53) | KARS1 | |
| SCHEMBL1704909 | 0.86 | KARS1 (0.67) | KARS1TBK1 | |
| SCHEMBL1704599 | 0.86 | CKS1B (0.51) | MAP4K4KITCKS1BSKP1SKP2 | |
| SCHEMBL1704340 | 0.85 | KARS1 (0.64) | KARS1CKS1BSKP1SKP2 | |
| SCHEMBL901674 | 0.85 | KARS1 (0.62) | KARS1TBK1CKS1BSKP1SKP2 | |
| SCHEMBL1704773 | 0.85 | KARS1 (0.51) | KARS1TBK1CKS1BSKP1SKP2 | |
| SCHEMBL1704297 | 0.80 | SYK (0.53) | KARS1MAP4K4TBK1CKS1BSKP1 | |
| SCHEMBL1704227 | 0.79 | KARS1 (0.73) | KARS1 | |
| SCHEMBL901333 | 0.77 | KARS1 (0.65) | KARS1TBK1KITCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |