Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 6/20 | 0.51 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | CKS1B | P61024 | 2/20 | 0.44 |
| ▸ | SKP1 | P63208 | 2/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901697 | 0.88 | KARS1 (0.65) | KARS1TBK1CKS1BSKP1SKP2 | |
| SCHEMBL1705645 | 0.88 | KARS1 (0.56) | KARS1TBK1RETLRRK2SYK | |
| SCHEMBL1704340 | 0.85 | KARS1 (0.64) | KARS1CKS1BSKP1SKP2 | |
| SCHEMBL901674 | 0.85 | KARS1 (0.62) | KARS1TBK1CKS1BSKP1SKP2 | |
| SCHEMBL1704884 | 0.85 | KARS1 (0.50) | KARS1TBK1ACHECKS1BSKP1 | |
| SCHEMBL1704909 | 0.84 | KARS1 (0.67) | KARS1TBK1SYK | |
| SCHEMBL1704417 | 0.81 | KARS1 (0.76) | KARS1 | |
| SCHEMBL1704599 | 0.80 | CKS1B (0.51) | ACHECKS1BSKP1SKP2RET | |
| SCHEMBL21744945 | 0.78 | RET (0.52) | RET | |
| SCHEMBL1704297 | 0.76 | SYK (0.53) | KARS1TBK1CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |