Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.51 |
| ▸ | SKP1 | P63208 | 2/20 | 0.51 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704884 | 0.86 | KARS1 (0.50) | CKS1BSKP1SKP2MAP4K4LRRK2 | |
| SCHEMBL902015 | 0.85 | ITGB2 (0.46) | CKS1BSKP1SKP2MAP4K4PIK3CA | |
| SCHEMBL902759 | 0.84 | ADORA2A (0.60) | CKS1BSKP1SKP2MAP4K4GPR119 | |
| SCHEMBL901638 | 0.84 | PRKD3 (0.43) | — | |
| SCHEMBL1580206 | 0.82 | CKS1B (0.52) | CKS1BSKP1SKP2MAP4K4LRRK2 | |
| SCHEMBL3443191 | 0.82 | CKS1B (0.64) | CKS1BSKP1SKP2MAP4K4LRRK2 | |
| SCHEMBL901697 | 0.81 | KARS1 (0.65) | CKS1BSKP1SKP2 | |
| SCHEMBL458906 | 0.81 | MAP4K4 (0.60) | CKS1BSKP1SKP2MAP4K4GPR119 | |
| SCHEMBL1704340 | 0.81 | KARS1 (0.64) | CKS1BSKP1SKP2GPR119 | |
| SCHEMBL30998101 | 0.80 | MAP4K4 (0.56) | CKS1BSKP1SKP2MAP4K4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |