Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17046823 | 1.00 | CA2 (0.41) | CA2CA1PRSS1PRSS2PRSS3 | |
| SCHEMBL17046824 | 1.00 | CA2 (0.41) | CA2CA1PRSS1PRSS2PRSS3 | |
| SCHEMBL1120219 | 0.79 | CA1 (0.44) | CA2CA1PRSS1PRSS2PRSS3 | |
| SCHEMBL1120216 | 0.79 | CA1 (0.44) | CA2CA1PRSS1PRSS2PRSS3 | |
| SCHEMBL10082509 | 0.74 | CA1 (0.50) | CA2CA1PRSS1PRSS2PRSS3 | |
| SCHEMBL88641 | 0.72 | CA2 (0.64) | CA2CA1PRSS1PRSS2PRSS3 | |
| SCHEMBL6555604 | 0.72 | CA1 (0.48) | CA2CA1PRSS1PRSS2PRSS3 | |
| SCHEMBL1169955 | 0.72 | CA1 (0.48) | CA2CA1PRSS1PRSS2PRSS3 | |
| SCHEMBL10563302 | 0.71 | MAOB (0.61) | CA2CA1ALDH1A1TSHR | |
| SCHEMBL9718255 | 0.71 | MAOB (0.61) | CA2CA1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3110412-B1 | 4-BENZYLSULFONYL-2-BUTENENITRILE | OLATEC THERAPEUTICS LLC (US) | 2018-10-31 | — | — | EP | claimed |
| US-9987246-B2 | 4-benzylsulfonyl-2-butenenitrile | OLATEC THERAPEUTICS LLC (US) | 2018-06-05 | — | — | US | claimed |
| EP-3110412-A1 | 4-BENZYLSULFONYL-2-BUTENENITRILE | Olatec Therapeutics LLC (US) | 2017-01-04 | — | — | EP | claimed |
| US-20160361286-A1 | 4-BENZYLSULFONYL-2-BUTENENITRILE | OLATEC THERAPEUTICS, INC. | 2016-12-15 | — | — | US | claimed |
| WO-2015130595-A1 | 4-BENZYLSULFONYL-2-BUTENENITRILE | OLATEC INDUSTRIES LLC (US) | 2015-09-03 | — | — | WO | claimed |
| US-9987246-B2 | 4-benzylsulfonyl-2-butenenitrile | OLATEC THERAPEUTICS LLC (US) | 2018-06-05 | — | — | US | disclosed |
| US-9987246-B2 | 4-benzylsulfonyl-2-butenenitrile | OLATEC THERAPEUTICS LLC (US) | 2018-06-05 | — | — | US | disclosed |
| US-20160361286-A1 | 4-BENZYLSULFONYL-2-BUTENENITRILE | OLATEC THERAPEUTICS, INC. | 2016-12-15 | — | — | US | disclosed |
| US-20160361286-A1 | 4-BENZYLSULFONYL-2-BUTENENITRILE | OLATEC THERAPEUTICS, INC. | 2016-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160361286-A1 | 4-BENZYLSULFONYL-2-BUTENENITRILE | IL4, NFKBIA, TRPV1 | CA2 774/4885CA1 3392/4885PRSS1 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.