Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.54 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20512567 | 0.86 | SOS1 (0.54) | SOS1CFTRNOTUMTSHRLMNA | |
| SCHEMBL31079873 | 0.84 | SOS1 (0.50) | SOS1NOTUMTSHRLMNANPSR1 | |
| SCHEMBL14349262 | 0.84 | SOS1 (0.50) | SOS1NOTUMTSHRLMNANPSR1 | |
| SCHEMBL365953 | 0.84 | SOS1 (0.50) | SOS1NOTUMTSHRLMNANPSR1 | |
| SCHEMBL30952071 | 0.83 | CFTR (0.56) | SOS1CFTRTSHRCA1CA2 | |
| SCHEMBL2316462 | 0.81 | SOS1 (0.48) | SOS1NOTUMTSHRLMNANPSR1 | |
| SCHEMBL15877820 | 0.81 | CA12 (0.44) | SOS1CFTRTSHRLMNACA12 | |
| SCHEMBL3411975 | 0.81 | SOS1 (0.48) | SOS1NOTUMTSHRLMNANPSR1 | |
| SCHEMBL31565672 | 0.81 | SOS1 (0.48) | SOS1NOTUMTSHRLMNANPSR1 | |
| SCHEMBL1044961 | 0.80 | SOS1 (0.46) | SOS1NOTUMTSHRLMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114437062-B | Compound capable of being used as sodium channel regulator and application thereof | 成都海博为药业有限公司 | 2024-05-17 | — | — | CN | disclosed |
| WO-2022127847-A1 | PYRIMIDONE DERIVATIVE AND APPLICATION THEREOF IN DRUG | 广东东阳光药业有限公司 | 2022-06-23 | — | — | WO | disclosed |
| WO-2022127847-A1 | PYRIMIDONE DERIVATIVE AND APPLICATION THEREOF IN DRUG | 广东东阳光药业有限公司 | 2022-06-23 | — | — | WO | disclosed |
| CN-114644628-A | Pyrimidone derivatives and their use in medicine | 广东东阳光药业有限公司 | 2022-06-21 | — | — | CN | disclosed |
| CN-114437062-A | Compound capable of being used as sodium channel regulator and application thereof | 成都海博为药业有限公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-108017603-B | Tricyclic compounds and uses thereof | 株式会社蒂奥姆生物 | 2021-07-23 | — | — | CN | disclosed |
| EP-2963027-B1 | TRICYCLIC COMPOUND AND USE THEREOF | TIUMBIO CO LTD (KR) | 2018-12-26 | — | — | EP | disclosed |
| US-10150787-B2 | TC-PTP inhibitors as APC activators for immunotherapy | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2018-12-11 | — | — | US | disclosed |
| US-20180265531-A1 | TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2018-09-20 | — | — | US | disclosed |
| US-10005804-B2 | TC-PTP inhibitors as APC activators for immunotherapy | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIV (CA) | 2018-06-26 | — | — | US | disclosed |
| US-20170015690-A1 | TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY | THE ROYAL INSTITUTE FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY (CA) | 2017-01-19 | — | — | US | disclosed |
| US-20170015690-A1 | TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY | THE ROYAL INSTITUTE FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY (CA) | 2017-01-19 | — | — | US | disclosed |
| US-20170015690-A1 | TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY | THE ROYAL INSTITUTE FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY (CA) | 2017-01-19 | — | — | US | disclosed |
| EP-3110824-A1 | TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY | The Royal Institution for the Advancement of Learning / McGill University (CA) | 2017-01-04 | — | — | EP | disclosed |
| US-20160009677-A1 | TRICYCLIC COMPOUND AND USE THEREOF | SK CHEMICALS CO., LTD. (KR) | 2016-01-14 | — | — | US | disclosed |
| US-20160009677-A1 | TRICYCLIC COMPOUND AND USE THEREOF | SK CHEMICALS CO., LTD. (KR) | 2016-01-14 | — | — | US | disclosed |
| US-20160009677-A1 | TRICYCLIC COMPOUND AND USE THEREOF | SK CHEMICALS CO., LTD. (KR) | 2016-01-14 | — | — | US | disclosed |
| EP-2963027-A1 | TRICYCLIC COMPOUND AND USE THEREOF | SK Chemicals Co., Ltd. (KR) | 2016-01-06 | — | — | EP | disclosed |
| EP-2963027-A1 | TRICYCLIC COMPOUND AND USE THEREOF | SK Chemicals Co., Ltd. (KR) | 2016-01-06 | — | — | EP | disclosed |
| WO-2015127548-A1 | TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY (CA) | 2015-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10005804-B2 | TC-PTP inhibitors as APC activators for immunotherapy | PTPRCAP, PTPRC, PTPA | SOS1 3602/4885CFTR 2962/4885NOTUM 2749/4885 |
| US-20170015690-A1 | TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY | PTPRCAP, PTPRC, PTPA | SOS1 3602/4885CFTR 2962/4885NOTUM 2749/4885 |
| US-20180265531-A1 | TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY | PTPRCAP, PTPRC, PTPA | SOS1 3602/4885CFTR 2962/4885NOTUM 2749/4885 |
| US-20160009677-A1 | TRICYCLIC COMPOUND AND USE THEREOF | GPR65, GPR119, GPR35 | SOS1 2781/4885CFTR 122/4885NOTUM 1257/4885 |
| US-10150787-B2 | TC-PTP inhibitors as APC activators for immunotherapy | PTPRCAP, PTPRC, PTPA | SOS1 3602/4885CFTR 2962/4885NOTUM 2749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.