Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.54 |
| ▸ | NAMPT | P43490 | 5/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901966 | 0.90 | KARS1 (0.61) | KARS1NAMPT | |
| SCHEMBL1705215 | 0.87 | KARS1 (0.62) | KARS1GPR119 | |
| SCHEMBL902898 | 0.87 | KARS1 (0.72) | KARS1NAMPT | |
| SCHEMBL1704251 | 0.86 | KARS1 (0.73) | KARS1GPR119 | |
| SCHEMBL902995 | 0.85 | KARS1 (0.67) | KARS1GPR119 | |
| SCHEMBL902682 | 0.84 | KARS1 (0.62) | KARS1GPR119 | |
| SCHEMBL1705312 | 0.84 | KARS1 (0.73) | KARS1GPR119 | |
| SCHEMBL1704902 | 0.84 | KARS1 (0.73) | KARS1GPR119 | |
| SCHEMBL902673 | 0.84 | KARS1 (0.65) | KARS1GPR119 | |
| SCHEMBL1704267 | 0.84 | KARS1 (0.63) | KARS1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |