Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.61 |
| ▸ | NAMPT | P43490 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902898 | 0.91 | KARS1 (0.72) | KARS1NAMPTROCK2 | |
| SCHEMBL1704968 | 0.90 | KARS1 (0.54) | KARS1NAMPT | |
| SCHEMBL901421 | 0.85 | KARS1 (0.82) | KARS1 | |
| SCHEMBL901757 | 0.85 | KARS1 (0.66) | KARS1 | |
| SCHEMBL1704272 | 0.82 | KARS1 (0.74) | KARS1 | |
| SCHEMBL902036 | 0.82 | KARS1 (0.81) | KARS1 | |
| SCHEMBL902003 | 0.82 | KARS1 (0.61) | KARS1 | |
| SCHEMBL901935 | 0.82 | KARS1 (0.65) | KARS1 | |
| SCHEMBL901801 | 0.81 | KARS1 (0.56) | KARS1 | |
| SCHEMBL901791 | 0.81 | KARS1 (0.81) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |