Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 11/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14020501 | 0.85 | KMO (0.51) | HSP90AA1FFAR1NPBWR1MCHR1HTR2A | |
| SCHEMBL17050946 | 0.85 | KDM4E (0.46) | HSP90AA1FFAR1NPBWR1MCHR1HTR2A | |
| SCHEMBL21820786 | 0.82 | HSP90AA1 (0.71) | HSP90AA1HTR2ASLC6A4KCNH2KMO | |
| SCHEMBL4366979 | 0.82 | ALDH1A1 (0.48) | MEN1KMT2AFNTAFNTB | |
| SCHEMBL15849015 | 0.82 | ALDH1A1 (0.48) | MEN1KMT2AFNTAFNTB | |
| SCHEMBL18805968 | 0.81 | ALDH1A1 (0.46) | NPBWR1MCHR1MEN1KMT2AFNTA | |
| SCHEMBL11175966 | 0.79 | HSP90AA1 (0.57) | HSP90AA1FFAR1HTR2ASLC6A4KCNH2 | |
| SCHEMBL632533 | 0.79 | MAOA (0.61) | HSP90AA1HTR2ASLC6A4KMOMEN1 | |
| SCHEMBL257844 | 0.79 | HSP90AA1 (0.57) | HSP90AA1FFAR1HTR2ASLC6A4KCNH2 | |
| SCHEMBL31287771 | 0.79 | HSP90AA1 (0.57) | HSP90AA1FFAR1HTR2ASLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9394261-B2 | Aryl amine substituted pyrimidine and quinazoline and their use as anticancer drugs | NATIONAL YANG-MING UNIVERSITY (TW) | 2016-07-19 | — | — | US | disclosed |
| US-20150246891-A1 | ARYL AMINE SUBSTITUTED PYRIMIDINE AND QUINAZOLINE AND THEIR USE AS ANTICANCER DRUGS | NATIONAL TAIWAN UNIVERSITY (TW) | 2015-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246891-A1 | ARYL AMINE SUBSTITUTED PYRIMIDINE AND QUINAZOLINE AND THEIR USE AS ANTICANCER DRUGS | EGFR, ERBB4, ERBB2 | HSP90AA1 2780/4885FFAR1 3347/4885NPBWR1 4631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.