Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | CCR8 | P51685 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14354842 | 0.83 | ALDH1A1 (0.41) | KDM4ENOS3NOS1NOS2PI4KA | |
| SCHEMBL7874577 | 0.78 | KDM4E (0.56) | KDM4EPIN1NOS3NOS1NOS2 | |
| SCHEMBL243134 | 0.78 | ALDH1A1 (0.53) | KDM4ECYP1A2POLBLTA4HALDH1A1 | |
| Hydrochloric Acid SCHEMBL9650595 | 0.78 | GRM4 (0.39) | KDM4EPIN1NOS3NOS1NOS2 | |
| SCHEMBL9765665 | 0.77 | KDM4E (0.46) | KDM4EPIN1NOS3NOS1NOS2 | |
| SCHEMBL17645216 | 0.77 | KDM4E (0.39) | KDM4EPIN1NOS3NOS1NOS2 | |
| SCHEMBL409030 | 0.76 | KDM4E (0.55) | KDM4EPIN1NOS3NOS1NOS2 | |
| SCHEMBL1340918 | 0.74 | ALDH1A1 (0.53) | CYP1A2ALDH1A1CYP3A4CYP2C19MEN1 | |
| SCHEMBL30359419 | 0.74 | RAB9A (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2MAPT | |
| Phosphine SCHEMBL17979775 | 0.74 | KDM4E (0.53) | KDM4EPIN1NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120277233-A1 | Pyridyl-Triazine Inhibitors of Hedgehog Signaling | CALIFORNIA CAPITAL EQUITY, LLC (US) | 2012-11-01 | — | — | US | disclosed |
| EP-2440054-A1 | PYRIDIL-TRIAZINE INHIBITORS OF HEDGEHOG SIGNALING | Abraxis BioScience, LLC (US) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010144404-A1 | PYRIDIL-TRIAZINE INHIBITORS OF HEDGEHOG SIGNALING | ABRAXIS BIOSCIENCE, LLC (US) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277233-A1 | Pyridyl-Triazine Inhibitors of Hedgehog Signaling | SHH, GLI1, SMO | KDM4E 1561/4885PIN1 285/4885NOS3 2473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.