Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660640 | 0.78 | TDP1 (0.54) | HTR1ASLC6A2SLC6A4CRHR1LMNA | |
| SCHEMBL4799563 | 0.78 | SMN1; SMN2 (0.62) | KDM4EHTR1ASLC6A2SLC6A4LMNA | |
| SCHEMBL4361112 | 0.78 | KDM4E (0.47) | KDM4ENOS3NOS1NOS2LMNA | |
| SCHEMBL10271917 | 0.78 | KEAP1 (0.59) | KDM4ENOS3NOS1NOS2HTR1A | |
| SCHEMBL1705163 | 0.77 | KDM4E (0.46) | KDM4ENOS3NOS1NOS2PIN1 | |
| Hydrochloric Acid SCHEMBL2964219 | 0.77 | SMN1; SMN2 (0.60) | KDM4EHTR1ASLC6A2SLC6A4LMNA | |
| SCHEMBL409030 | 0.76 | KDM4E (0.55) | KDM4ENOS3NOS1NOS2PIN1 | |
| SCHEMBL29716346 | 0.76 | KMT2A (0.45) | KDM4ENOS3NOS1NOS2HTR1A | |
| SCHEMBL22061929 | 0.76 | KMT2A (0.45) | KDM4ENOS3NOS1NOS2HTR1A | |
| SCHEMBL15074670 | 0.74 | HTR1A (0.54) | KDM4EHTR1ASLC6A2SLC6A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-02-01 | — | — | US | disclosed |
| EP-0440784-A1 | PREPARATION OF DI-CATION ETHERS. | EASTMAN KODAK CO (US) | 1991-08-14 | — | — | EP | disclosed |
| WO-1991003465-A1 | PREPARATION OF DI-CATION ETHERS | EASTMAN KODAK COMPANY (US) | 1991-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | GRM5, GRIK5, GRM1 | KDM4E 327/4885NOS3 4497/4885NOS1 4628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.