Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | PANK3 | Q9H999 | 4/20 | 0.37 |
| ▸ | ME2 | P23368 | 1/20 | 0.36 |
| ▸ | ME1 | P48163 | 1/20 | 0.36 |
| ▸ | ME3 | Q16798 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11945490 | 0.84 | MAPT (0.38) | POLBMAPTALDH1A1DCTPP1LMNA | |
| SCHEMBL17058186 | 0.83 | MCHR1 (0.34) | — | |
| SCHEMBL17058282 | 0.79 | MCHR1 (0.37) | KMT2AMEN1ALDH1A1DCTPP1HPGD | |
| SCHEMBL11944627 | 0.78 | MAPT (0.39) | POLBMAPTALDH1A1DCTPP1LMNA | |
| SCHEMBL11944633 | 0.78 | MAPT (0.39) | POLBMAPTALDH1A1DCTPP1HSD17B10 | |
| SCHEMBL17058160 | 0.74 | MAPT (0.46) | POLBL3MBTL1ME2ME1ME3 | |
| SCHEMBL17058334 | 0.73 | MCHR1 (0.35) | KMT2AMEN1ALDH1A1HPGDLMNA | |
| SCHEMBL11952988 | 0.72 | MAPT (0.38) | POLBMAPTALDH1A1DCTPP1CYP3A4 | |
| SCHEMBL17057930 | 0.71 | POLB (0.45) | POLBL3MBTL1KMT2AMAPTMEN1 | |
| SCHEMBL17058518 | 0.71 | LMNA (0.41) | L3MBTL1KMT2AMAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |