Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11943439 | 0.94 | MAPT (0.45) | KMT2AHRH1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL14081533 | 0.88 | ALDH1A1 (0.46) | KMT2AALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL17057983 | 0.87 | MAPT (0.46) | KMT2AMEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11943446 | 0.86 | SIGMAR1 (0.46) | KMT2AALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL11943341 | 0.84 | SIGMAR1 (0.48) | KMT2AMEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL14080963 | 0.82 | NPC1 (0.43) | KMT2AMEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11943323 | 0.81 | ALDH1A1 (0.42) | KMT2AHRH1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11943442 | 0.81 | ALDH1A1 (0.42) | KMT2AMEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11943436 | 0.80 | SIGMAR1 (0.43) | KMT2AALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL11943820 | 0.80 | HTR1A (0.39) | ALDH1A1LMNAPOLBSIGMAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |