Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17057966 | 0.86 | ALDH1A1 (0.36) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL17057972 | 0.83 | POLB (0.33) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL17058559 | 0.82 | POLB (0.33) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL17058218 | 0.82 | ALDH1A1 (0.31) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL11945638 | 0.81 | CYP2C19 (0.40) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL17057853 | 0.80 | SMN1; SMN2 (0.35) | POLBCYP3A4CYP2C19PPARGNCOA2 | |
| SCHEMBL17058464 | 0.80 | ALDH1A1 (0.32) | POLBALDH1A1SMN1; SMN2DCTPP1RXFP1 | |
| SCHEMBL17058224 | 0.80 | DCTPP1 (0.40) | POLBNPSR1ALDH1A1SMN1; SMN2DCTPP1 | |
| SCHEMBL14080902 | 0.79 | NPBWR1 (0.31) | — | |
| SCHEMBL17058239 | 0.78 | NPBWR1 (0.32) | POLBCYP3A4CYP2C19PPARGNCOA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |