Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11943323 | 0.93 | ALDH1A1 (0.42) | LMNAALDH1A1POLBMAPTMAPK1 | |
| SCHEMBL11943436 | 0.89 | SIGMAR1 (0.43) | LMNAALDH1A1POLBMAPTMAPK1 | |
| SCHEMBL11943398 | 0.86 | SMN1; SMN2 (0.42) | LMNAALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL11943445 | 0.85 | ALDH1A1 (0.49) | LMNAALDH1A1POLBMAPTMAPK1 | |
| SCHEMBL17058530 | 0.84 | MAPT (0.49) | LMNAALDH1A1POLBMAPTMAPK1 | |
| SCHEMBL11943367 | 0.83 | NPC1 (0.40) | LMNAALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL11943444 | 0.83 | NPBWR1 (0.43) | LMNAALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL11943405 | 0.82 | DRD2 (0.40) | LMNAALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL11943366 | 0.81 | SMO (0.47) | LMNAALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL11943369 | 0.81 | ALDH1A1 (0.41) | LMNAALDH1A1MAPTHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115381-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |