Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC2 | O75106 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL600409 | 0.84 | AOC2 (0.42) | AOC2CDK4CDK2CNR2ALDH1A1 | |
| SCHEMBL601536 | 0.74 | RIPK2 (0.44) | AOC2CDK4CDK2CNR2MEN1 | |
| SCHEMBL2592939 | 0.73 | RIPK2 (0.62) | CDK4CDK2 | |
| SCHEMBL17059494 | 0.72 | TXNRD1 (0.39) | ALDH1A1LMNAMEN1KMT2AKDM4E | |
| SCHEMBL17059467 | 0.70 | RIPK2 (0.36) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL17059460 | 0.70 | RIPK2 (0.48) | KDM4E | |
| SCHEMBL23370065 | 0.68 | AOC2 (0.55) | AOC2ALDH1A1SMN1; SMN2NR2F2RAB9A | |
| SCHEMBL8643198 | 0.68 | AOC2 (0.55) | AOC2ALDH1A1SMN1; SMN2NR2F2RAB9A | |
| SCHEMBL5140258 | 0.68 | AOC2 (0.55) | AOC2ALDH1A1SMN1; SMN2NR2F2RAB9A | |
| SCHEMBL30361453 | 0.68 | AOC2 (0.55) | AOC2CDK4CDK2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-B1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2015-09-02 | — | — | EP | disclosed |